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Based on limited information, topiramate has also been associated with pre-term labor and premature delivery. Data Human Data Data from pregnancy registries indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. It was also higher than the background prevalence in United States 0.
The UK Epilepsy and Pregnancy Register Topamax generic Purchase a prevalence of oral clefts among infants exposed to topiramate monotherapy 3. The long-term consequences of the SGA findings are not known. Fetal body weights and skeletal ossification were Topamax generic Purchase at the highest dose tested in conjunction with decreased maternal body weight gain. A no-effect dose for embryofetal developmental toxicity in mice was not identified. The no-effect dose 2. When topiramate 0, 0. The no-effect dose 0.
Lactation Risk Summary Topiramate is excreted in Topamax generic Purchase milk. The effects of topiramate on milk production are unknown. Diarrhea and somnolence have been reported in breastfed infants whose mothers receive topiramate treatment.
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While using Topamax, you may need frequent blood tests. If you need surgery, tell the surgeon ahead of time that you are using this medicine. Any Topamax generic Purchase care provider who treats you should know that you take seizure medication. Do not stop using Topamax suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Call your doctor if your seizures get worse or you have them more often while taking Topamax. Store at cool room temperature away from moisture, light, and high heat.
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- Mutagenesis Topiramate did not demonstrate genotoxic potential when tested in a battery of in vitro and in vivo assays.
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Topiramate can decrease sweating and increase body temperature, leading to life-threatening dehydration especially in children.